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La PDE5 è la fosfodiesterasi predominante nei vasi polmonari. L’inibizione della PDE5 da parte di tadalafil aumenta le concentrazioni della cGMP determinando un rilassamento della muscolatura liscia dei vasi polmonari e una vasodilatazione del letto vascolare polmonare.
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In caso di sovradosaggio, devono essere adottate le necessarie misure regular di supporto. L’emodialisi contribuisce in modo trascurabile all’eliminazione del tadalafil. Cialis: avvertenze e precauzioni
Il trattamento con un inibitore della fosfodiesterasi di tipo five aumenta la quantità e la permanenza del fake viagra NO in loco e quindi prolunga e accentua questo rilassamento.